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Truth serum
Thiopental is still used in some places as a truth serum.[8] The barbiturates as a class decrease higher cortical brain functioning. Psychiatrists hypothesize that because lying is more complex than telling the truth, suppression of the higher cortical functions may lead to the uncovering of the "truth". However, the reliability of confessions made under thiopental is dubious; the drug tends to make subjects chatty and cooperative with interrogators, but a practiced liar or someone who has a false story firmly established would still be quite able to lie while under the influence of the drug.[citation needed]

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Originally posted by citizen:
I believe it's more like alcohol, in that it makes someone more talkative and lowers inhibitions, not necessarily more truthful. Getting someone blasted can be away of getting what they really think out of them, but it's not exactly reliable.

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