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Do gut bacteria (or lack of) cause autism?

POSTED BY: SIGNYM
UPDATED: Tuesday, June 4, 2019 20:15
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Saturday, June 1, 2019 12:13 PM

SIGNYM

I believe in solving problems, not sharing them.


I have heard of fecal matter transplant (FMT) literally curing severe cases of Crohns Disease.

Crohn's disease is an inflammatory bowel diease where the intestines literally liquefies and shreds away. The people that FMT cured had undergone numerous aggressive treatments for their condition, starting with antibiotics, then short courses of steroids then longer courses of high=dose steroids, then courses of immuno-suppressive agents like methodtrextae and cyclosporine (an anti-rejection drug) and finally surgery to remove the abscesses and masses of inflammed tissues. Here is a study of the results of using FMT for Crohn's disease ...

https://www.nature.com/articles/s41598-017-04984-z

However, researchers are reporting progress in using FMT (now called microbiota transfer therapy, MTT) in treating autism.

Quote:

... They found that the children in their sample were missing hundreds of the thousand-plus bacterial species that colonise a “neurotypical” person’s intestine. One notable absence was Prevotella. This bug, which makes its living by fermenting otherwise-indigestible carbohydrate polymers in dietary fibre, is abundant in the alimentary canals of farmers and hunter-gatherers in places like Africa, rare in western Europeans and Americans, and nearly nonexistent in children with ASD.

Their discovery led Dr Krajmalnik-Brown and Dr Adams to the idea that restoring the missing bacteria might alleviate autism’s symptoms. Two years ago they tested a process called microbiota transfer therapy (MTT) on 18 autistic children aged between seven and 16. Of their participants 15 were regarded, according to the Childhood Autism Rating Scale, as having “severe” autism.

MTT is a prolonged version of a process already used to treat infection by a bug called Clostridium difficile, which causes life-threatening diarrhoea. It involves transplanting carefully prepared doses of faecal bacteria from a healthy individual to a patient. The researchers gave the children, first, an oral antibiotic, a bowel cleanse and an oral antacid (to ensure that microbes administered by mouth would survive their passage through the stomach). They followed this up with either an oral or a rectal dose of gut bacteria, and then, for seven to eight weeks, a daily antacid-assisted oral dose.

Ten weeks after treatment started the children’s Prevotella levels had multiplied 712-fold. In addition, those of another species, Bifidobacterium, had quadrupled. Bifidobacterium is what is known as a “probiotic” organism—something that acts as a keystone species in the alimentary ecosystem, keeping the mixture of gut bacteria healthy. Now, two years later, although levels of Prevotella have fallen back somewhat, they are still 84 times higher than they were before the experiment started. Levels of Bifidobacterium, meanwhile, have gone up still further—being five times higher than they had been at the beginning of the study. This, says Dr Krajmalnik-Brown, suggests the children’s guts have become healthy environments that can recruit beneficial microbes by themselves.

Crucially, these changes in gut bacteria have translated into behavioural changes. Even 18 weeks after treatment started the children had begun showing reduced symptoms of autism. After two years, only three of them still rated as severe, while eight fell below the diagnostic cut-off point for ASD altogether. These eight thus now count as neurotypical...

The article goes on to describe a possible mechansim for HOW the bacteria might change brain function, here ...
https://www.economist.com/science-and-technology/2019/05/30/more-evide
nce-that-autism-is-linked-to-gut-bacteria?utm_source=pocket-newtab







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Saturday, June 1, 2019 12:39 PM

SIGNYM

I believe in solving problems, not sharing them.


Now, to carry this thought further ... one complaint that epidemiologists, animal rights activists, doctors, other health specialists, and environmentalists have been making for years is the over-use of antibiotics in factory-farming.

Cows for example are no adapated to grain-eating; cows naturally eat grass and hay (dried grass). But because grass-fed cattle grow more slowly and are too lean for modern palates, they are often fed large amounts of grain to fatten them up for slaughter. The grain causes ulcers of the mouth and stomach, massive diarrhea, acidosis, and general ill-health, so these fattening operations rely on a constant dose of antibiotics to keep their animals ... well, not healthy, but at least gaining weight.

This means that not only do the animals live with an impoverished population of gut bacteria but that people are exposed to constant low-dose antibiotics and antibiotic=resistant bacteria.

Aside from the "usual suspects", GLYPHOSATE (Roundup) weed-killer, massively sprayed on glyphosate-resistant GMO corn, GMO soy, GMO sugar beets and other GMO crops multiple times per year, is ALSO an antibiotic.

Monsanto actually took out an additional patent on glyphosate as an anti-microbial agent; here is a portion of that patent

Quote:

The observations that both chemical and genetic inhibition of the shikimate pathway results in reduced cell viability has stimulated interest in the pathway as a possible target for drug therapy in acute microbial infection. It is likely that compounds which can inhibit the activity of shikimate enzymes will not cause cell death of the infecting microbe, but will result in attenuation in a manner analagous to the phenotype of shikimate pathway mutants. As antimicrobials, these compounds may be expected to induce stasis rather than cell lysis or death, allowing the infection to be cleared by the host's immune system. Such an outcome is desirable as it will ameliorate the absolute selective pressure to select for the growth of resistant mutants which would inevitably be the case if the compounds used caused cell death.


https://patents.google.com/patent/US7771736

Apparently, we are awash in antibiotics from all directions.

I've often said that I thought that the rapid increase in autism would be found in something stupid and simple. Maybe lack of sunlight, as everyone slathered on sunscreen. Maybe lack of choline, as everyone ran away from eating eggs. Maybe lack of omega-3 or taurine, as the Catholic "fish Friday" fell into disfavor.

But maybe it's lack of bacteria.

-----------
Pity would be no more,
If we did not MAKE men poor - William Blake

"The messy American environment, where most people don't agree, is perfect for people like me. I CAN DO AS I PLEASE." - SECOND

America is an oligarchy http://www.fireflyfans.net/mthread.aspx?tid=57876 .

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Saturday, June 1, 2019 2:33 PM

6IXSTRINGJACK


It's possible.

There have been studies done that have shown that gut microbes are directly related to cravings that people have.

The more we learn about this type of stuff, the more fascinating it becomes, really. When I grew up, I thought when I had a craving for something like a pizza that it was my own idea. Then you find out later in life that it's actually something in the pizza (or whatever food you're craving) that your body might be looking for. Then, you find out that (especially in the case of all things gluten) that gut microbes that have been allowed to flourish in a diet heavy in breads and pastas are essentially using a rudimentary form of mind control on their host to ingest more of it.


Going gluten free was seriously tough at first, at least for 2 or 3 months. It's a huge lifestyle change for sure, but the cravings after only a few days were on the level of needing a cigarette. It's hard to power through and avoid eating pizza on rare occurrences like at work when they feed us. But that's really just because pizza tastes really damn good and it smells phenomenal when you haven't had it for over a year.

But I'd just walk right outside and have my cigarette and coffee and forget completely about it now, where when I first went gluten free the cravings would not have let me stop thinking about it for a second.



Who knows what other mental effects gut microbes could have on a person. Or side effects of just trying to get the host to eat a particular food over a prolonged period of time. Then throw in the fact that everybody is in many ways very different on a biological level and what effects one person drastically might have little to no effect on another person.



Do Right, Be Right. :)

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Saturday, June 1, 2019 3:07 PM

JEWELSTAITEFAN


Quote:

Originally posted by SIGNYM:
I have heard of fecal matter transplant (FMT) literally curing severe cases of Crohns Disease.

Crohn's disease is an inflammatory bowel diease where the intestines literally liquefies and shreds away. The people that FMT cured had undergone numerous aggressive treatments for their condition, starting with antibiotics, then short courses of steroids then longer courses of high=dose steroids, then courses of immuno-suppressive agents like methodtrextae and cyclosporine (an anti-rejection drug) and finally surgery to remove the abscesses and masses of inflammed tissues. Here is a study of the results of using FMT for Crohn's disease ...

https://www.nature.com/articles/s41598-017-04984-z

However, researchers are reporting progress in using FMT (now called microbiota transfer therapy, MTT) in treating autism.

Quote:

... They found that the children in their sample were missing hundreds of the thousand-plus bacterial species that colonise a “neurotypical” person’s intestine. One notable absence was Prevotella. This bug, which makes its living by fermenting otherwise-indigestible carbohydrate polymers in dietary fibre, is abundant in the alimentary canals of farmers and hunter-gatherers in places like Africa, rare in western Europeans and Americans, and nearly nonexistent in children with ASD.

Their discovery led Dr Krajmalnik-Brown and Dr Adams to the idea that restoring the missing bacteria might alleviate autism’s symptoms. Two years ago they tested a process called microbiota transfer therapy (MTT) on 18 autistic children aged between seven and 16. Of their participants 15 were regarded, according to the Childhood Autism Rating Scale, as having “severe” autism.

MTT is a prolonged version of a process already used to treat infection by a bug called Clostridium difficile, which causes life-threatening diarrhoea. It involves transplanting carefully prepared doses of faecal bacteria from a healthy individual to a patient. The researchers gave the children, first, an oral antibiotic, a bowel cleanse and an oral antacid (to ensure that microbes administered by mouth would survive their passage through the stomach). They followed this up with either an oral or a rectal dose of gut bacteria, and then, for seven to eight weeks, a daily antacid-assisted oral dose.

Ten weeks after treatment started the children’s Prevotella levels had multiplied 712-fold. In addition, those of another species, Bifidobacterium, had quadrupled. Bifidobacterium is what is known as a “probiotic” organism—something that acts as a keystone species in the alimentary ecosystem, keeping the mixture of gut bacteria healthy. Now, two years later, although levels of Prevotella have fallen back somewhat, they are still 84 times higher than they were before the experiment started. Levels of Bifidobacterium, meanwhile, have gone up still further—being five times higher than they had been at the beginning of the study. This, says Dr Krajmalnik-Brown, suggests the children’s guts have become healthy environments that can recruit beneficial microbes by themselves.

Crucially, these changes in gut bacteria have translated into behavioural changes. Even 18 weeks after treatment started the children had begun showing reduced symptoms of autism. After two years, only three of them still rated as severe, while eight fell below the diagnostic cut-off point for ASD altogether. These eight thus now count as neurotypical...

The article goes on to describe a possible mechansim for HOW the bacteria might change brain function, here ...
https://www.economist.com/science-and-technology/2019/05/30/more-evide
nce-that-autism-is-linked-to-gut-bacteria?utm_source=pocket-newtab


Did you find any mention of these bacteria being slaughtered with vaccines? Or any similar correlation, relationship?

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Saturday, June 1, 2019 5:18 PM

SIGNYM

I believe in solving problems, not sharing them.


As far as I know there's no relationship between vaccines and gut bacteria.

Vaccines cause brain damage in some children, especially the old-fashioned pertussis vaaccine. I knew one child personally (in dear daughter's class) and I knew of one online (child neurology forum) who were vaccinated and suffered brain damage. But the reaction was immediate and catastrophic, there was nothing subtle or questionable about it.

In the case of the child I learned about online, he had a seizure after his first set of vaccines and the doctor persuaded mom that it was just a febrile seizure and that he should get his second set. The second set caused massive seizures and massive brain damage, mom suffered unending guilt and pangs of regret for having been persuaded by doctor, against her better judgment, to go ahead with the second vaccination.



-----------
Pity would be no more,
If we did not MAKE men poor - William Blake

"The messy American environment, where most people don't agree, is perfect for people like me. I CAN DO AS I PLEASE." - SECOND

America is an oligarchy http://www.fireflyfans.net/mthread.aspx?tid=57876 .

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Tuesday, June 4, 2019 8:15 PM

JEWELSTAITEFAN


Quote:

Originally posted by SIGNYM:
As far as I know there's no relationship between vaccines and gut bacteria.

Vaccines cause brain damage in some children, especially the old-fashioned pertussis vaaccine. I knew one child personally (in dear daughter's class) and I knew of one online (child neurology forum) who were vaccinated and suffered brain damage. But the reaction was immediate and catastrophic, there was nothing subtle or questionable about it.

In the case of the child I learned about online, he had a seizure after his first set of vaccines and the doctor persuaded mom that it was just a febrile seizure and that he should get his second set. The second set caused massive seizures and massive brain damage, mom suffered unending guilt and pangs of regret for having been persuaded by doctor, against her better judgment, to go ahead with the second vaccination.

So the autism cases spurred by vaccinations are caused by something else, not related to gut bacteria?

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