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Originally posted by Brenda:
Out for my walk but I have to put my hearing aides on and I am really starting to hate them.

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Originally posted by SIGNYM:

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Originally posted by Brenda:
Out for my walk but I have to put my hearing aides on and I am really starting to hate them.

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I have one of those $20 hearing aids bc my hearing isn't very good either, and I hate them too. They make my ears itch, among other things. But for the sake of my family, I should put at least one in. Maybe I'll switch between ears so I don't get any fungal infections?

I noticed that altho my hearing is overall not so good (especially in the high frequencies) it also tends to come and go. Some (rare) days, I hear my glucose meter beep clear as anything, but most days not at all. I wonder if part of my problems is just allergy congestion . Altho I'm doing everything possible to tamp them down, I'm probably being exposed to allergens I don't even know about.

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"It may be dangerous to be America's enemy, but to be America's friend is fatal." - Henry Kissinger

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Originally posted by Brenda:
Out for my walk but I have to put my hearing aides on and I am really starting to hate them.

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Originally posted by 6IXSTRINGJACK:
Meds will need to be adjusted. It's possible I won't be on insulin for the long term and I just needed to give my pancreas a break from all those years of eating several dry cups worth of brown rice and all my other sugar sources every night.

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Growing up in a Republic was nice... Shame we couldn't keep it.

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Originally posted by Brenda:
Back from mah jong and vampires. No luck at mah jong but the vampires went smooth.

All medical tests now completed.

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Originally posted by SIGNYM:

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Originally posted by Brenda:
Back from mah jong and vampires. No luck at mah jong but the vampires went smooth.

All medical tests now completed.

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Smooth sailing then, at least for six months??

Wahoo!!

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"It may be dangerous to be America's enemy, but to be America's friend is fatal." - Henry Kissinger

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Originally posted by SIGNYM:

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Originally posted by 6IXSTRINGJACK:
Meds will need to be adjusted. It's possible I won't be on insulin for the long term and I just needed to give my pancreas a break from all those years of eating several dry cups worth of brown rice and all my other sugar sources every night.

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Growing up in a Republic was nice... Shame we couldn't keep it.

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Oh, I hope!!!

Fingers crossed!

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Originally posted by Brenda:
Out for my walk in a bit. Something to go back to the library.

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Originally posted by SIGNYM:
Well, people's metabolisms do adjust to their food. If you're eating a high fat low carb diet, your body will adapt to burn fat. If you're eating a high protein low everything else diet your body will adapt to burning protein.

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Originally posted by SIGNYM:

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Originally posted by Brenda:
Out for my walk in a bit. Something to go back to the library.

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I hope the weather is pleasant in your corner BRENDA!

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"It may be dangerous to be America's enemy, but to be America's friend is fatal." - Henry Kissinger

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Originally posted by SIGNYM:
Oh that's too bad, SIX. I'm sure that's unwelcome news

But-"C-protein"? As in 'C reactive protein'? Usually a generalized marker for inflammation, kind of like sed rate (sedimentation rate).

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I mentioned "C Peptide", if that's what you're asking. It's a way that they can measure how much insulin your pancreas creates even if you're taking insulin because for every unit of insulin made, your pancreas also releases an equal part "C-Peptide". So instead of measuring the amount of insulin in your body, that's what they measure.

A normal healthy person at any given time should have a result somewhere around 1.5. A Type II diabetic would usually have even higher than that because your pancreas would be trying to overcompensate for the insulin resistance. Mine was a .3. That's still considered on the very lowest end of the cusp for Type II, where .2 or below is considered Type I. This means a lot of my pancreas function has already been destroyed by the auto-immune response, and without immunotherapy that may or may not even work it will only get worse.

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It sounds tho like they've made a lot of progress in identifying the responsible antibodies, and they've made great progress in shutting off very specific parts of the immune system, so there's hope that in the near to intermediate term (ie. in your lifetime) they can figure out a cure. Yes, it would require perhaps stem cell treatment or cell/organ transplant, but this is such a common problem I'll bet there are a zillion researchers working on it.

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There are procedures that they already do, but they come with a lot of risks. I'd never get a pancreas transplant, and I don't think they'd even consider giving me one anyhow. The more promising option would be islet cell transplantation, but even though I meet many if not most of the qualifications for it, my heart issue might prevent me from being considered depending on how bad it is, and the fact that I smoke might preclude me from it entirely. And unless the science went a lot further on that I don't think I'd even consider it right now anyhow. Sometimes it takes 2 or 3 procedures to stick, I'd likely be on drugs to prevent my body from rejecting the transplant the rest of my life, and those drugs have been known to cause cancer. Furthermore, it seems like a temporary thing that has been shown to give anywhere from 6 months to 5 years without the need for insulin shots. I don't see any point of putting myself through that for only 6 months to 5 years without shots.

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Just FYI, autoimmune diseases tend to run in families. So if mom had MS, kid might get lupus. If dad had rheumatoid arthritis, kid might develop psoriasis.

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Too bad we don't get to pick which one we get. My mom and I appear to have drawn the short straws.

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Growing up in a Republic was nice... Shame we couldn't keep it.

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Originally posted by SIGNYM:
Well, you know the advice they give on how to live a long healthy life?

Pick your parents!

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That's just as true for your mental state as it is your physical.

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Well, I got a rare cancer promoting gene from somebody, and apparentlyy mom's weird autoimmune cartilage/ pseudo gout, my dad's extensive allergies, and whacky high cholesterol from somebody. It is what it is!

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Brenda:

Arthritis runs in my family. Badly on my dad's side. His mother but it missed all her children and is hitting the grandchildren. I had one cousin have all the joints in her fingers and toes replaced. Another cousin has it in a shoulder and my brother has it in his hands.

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Originally posted by 6IXSTRINGJACK:

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Originally posted by SIGNYM:
Well, you know the advice they give on how to live a long healthy life?

Pick your parents!

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That's just as true for your mental state as it is your physical.

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Well, I got a rare cancer promoting gene from somebody, and apparentlyy mom's weird autoimmune cartilage/ pseudo gout, my dad's extensive allergies, and whacky high cholesterol from somebody. It is what it is!

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Brenda:

Arthritis runs in my family. Badly on my dad's side. His mother but it missed all her children and is hitting the grandchildren. I had one cousin have all the joints in her fingers and toes replaced. Another cousin has it in a shoulder and my brother has it in his hands.

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Well you know what they say...





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Growing up in a Republic was nice... Shame we couldn't keep it.

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Originally posted by 6IXSTRINGJACK:
Well... Screw the hospital for posting my blood work results after 5:00PM on a Friday, but I don't need a Doctor to tell me that it's officially LADA, aka Type 1.5 Diabetes... which may as well just be Type I by a different name.

My GAD-65 test came in. A healthy person has a GAD reading of 0 to 5. Mine is over 500.

I have an auto-immune disease, and that's why I got Diabetes. So, Second, because I know you read everything I post... You can go get fucked. There's nothing I did that caused this. I'm no more responsible for my Diabetes diagnosis than my mom was for her MS diagnosis.


This might also explain a host of other issues I've had over the years. Things like becoming progressively "clumsier" and dropping tools when I'm working on something, and losing my balance sometimes while walking. It would explain why I couldn't find a gallon of milk I was sure I didn't finish a few months ago, only to find it the next day curdled in one of my kitchen cupboards.



So I guess that any success I have with oral medication right now will be short lived and it's injections for the rest of my life. There's no stopping this. I'm only postponing the inevitable now, and because I'm catching it so late that my C Peptide is already showing only .3 I'm surprised I'm getting any positive results from the oral medication at all anymore.

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SECOND: 6ix, are you a member of the Stray Cosmic Ray School of Human Doom? They are big believers in shifting the blame away from themselves and moving blame to uncontrollable random forces such as Cosmic Rays altering their genes or blaming vast enemies such as George Soros or Walt Disney or the Democratic Party. Where you went wrong, 6ix, is not going regularly to the doctor. I have not been sick in the 21st Century but I still go to the doctor every year. I have not had cavities in my life, but I still go to the dentist for tooth cleaning. My eyesight is better than 20-20, but I still go to the optometrist. On the other hand, I know Trump voters with bleeding cancers on their faces who will not go to a dermatologist because it is no big deal to have blemishes. Delaying having cancer removed ended up being the end of them.

6ix, remember that not everyone who smokes dies of cancer so that is the perfect excuse to keep smoking.

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The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.

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It’s clear that genetics play a role in autoimmune disease, but researchers still don’t fully understand how. For example, having a family member with lupus or multiple sclerosis (MS) raises your risk of getting these diseases. Some families have multiple members affected by different autoimmune diseases. However, genetics alone isn’t enough to cause autoimmune disease.

“We know that genes are important, but they aren’t everything,” Orbai says. “You can have family members with lupus or MS and never get them yourself. You can even test positive for lupus-specific DNA and still not have the disease.”

It’s possible that autoimmune disease occurs based on the immune system’s ability to handle stress. Orbai says that this is an area of intense research. “When does the stress on your body exceed your immune system’s ability to handle it? If we knew this, it could be the key to preventing autoimmune disease before it develops.”

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Researchers still don’t know what causes most autoimmune diseases. But they’ve made progress in understanding what puts you at risk and figuring out ways to diagnose and treat them.

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Originally posted by 6IXSTRINGJACK:
What the shit?

I went to bed and I'd gone down to 100. It was a straight line until 2:00AM and all the sudden it took off like a rocket. My alarm alerts me if I hit 200 and repeats every half hour so I must have missed the first one because I just woke up to this one at 4:30 and I'm 267! I haven't been over 250 since I got that monitor installed.

100 is the lowest that I've ever gone to sleep at.

I think I'm onto something about my liver dumping sugar into my system because I'm not eating all those carbs right before I go to sleep anymore. I finally go to sleep at a level a normal person goes to sleep at and by the rate I'm increasing I'll be up to over 300 before 6:00AM.

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Originally posted by 6IXSTRINGJACK:

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Originally posted by 6IXSTRINGJACK:
What the shit?

I went to bed and I'd gone down to 100. It was a straight line until 2:00AM and all the sudden it took off like a rocket. My alarm alerts me if I hit 200 and repeats every half hour so I must have missed the first one because I just woke up to this one at 4:30 and I'm 267! I haven't been over 250 since I got that monitor installed.

100 is the lowest that I've ever gone to sleep at.

I think I'm onto something about my liver dumping sugar into my system because I'm not eating all those carbs right before I go to sleep anymore. I finally go to sleep at a level a normal person goes to sleep at and by the rate I'm increasing I'll be up to over 300 before 6:00AM.

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I never did go up to 300. It looks like it peaked shortly after I woke up at around 280 and then came crashing right back down as fast as it went up. It's unknown if that's because I was awake and I drank a good deal of water or not (not because I was thirsty at all, but just an attempt to bring it back down). It should also be noted that I did not wake up because of the high blood sugar OR the need to urinate. I woke up because my beeping meter warning me of the high level woke me up.

The meter shows that not only did I go to sleep around 110, but it had actually (gradually) fallen as low as 90 on its own roughly 30 minutes before the spike happened. After falling, it never went down close to 90. I've been basically a straight line ever since, right in the area of +/-5 to 145.


This was NOT a waking phenomena. This was more akin to the Somogyi Effect, which for the past 90+ years has never been considered to be a fact and still remains a theory. I really wish I could get in touch with a GREAT doctor that knows a good deal about this stuff. I believe that with my previous extreme eating behaviors (specifically relating to massive carb loading in a short window before bedtime) and how my body reacts to what it considers low blood sugar at night now that I'm not eating all those carbs before bed is study-worthy and may be able to provide the community with some insight that it might not otherwise have been able to (legally) obtain.

I'm pretty sure that forcing or otherwise coercing somebody to eat the way that I did for as many years as I have in the name of science would be considered highly unethical, if not an outright violation of the Nuremberg Code. But here I am... All dialed in and ready to provide the data for the right person to study it.

You got any ideas about that, Sigs?

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Growing up in a Republic was nice... Shame we couldn't keep it.

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Originally posted by SIGNYM:

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Originally posted by 6IXSTRINGJACK:

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Originally posted by 6IXSTRINGJACK:
What the shit?

I went to bed and I'd gone down to 100. It was a straight line until 2:00AM and all the sudden it took off like a rocket. My alarm alerts me if I hit 200 and repeats every half hour so I must have missed the first one because I just woke up to this one at 4:30 and I'm 267! I haven't been over 250 since I got that monitor installed.

100 is the lowest that I've ever gone to sleep at.

I think I'm onto something about my liver dumping sugar into my system because I'm not eating all those carbs right before I go to sleep anymore. I finally go to sleep at a level a normal person goes to sleep at and by the rate I'm increasing I'll be up to over 300 before 6:00AM.

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I never did go up to 300. It looks like it peaked shortly after I woke up at around 280 and then came crashing right back down as fast as it went up. It's unknown if that's because I was awake and I drank a good deal of water or not (not because I was thirsty at all, but just an attempt to bring it back down). It should also be noted that I did not wake up because of the high blood sugar OR the need to urinate. I woke up because my beeping meter warning me of the high level woke me up.

The meter shows that not only did I go to sleep around 110, but it had actually (gradually) fallen as low as 90 on its own roughly 30 minutes before the spike happened. After falling, it never went down close to 90. I've been basically a straight line ever since, right in the area of +/-5 to 145.


This was NOT a waking phenomena. This was more akin to the Somogyi Effect, which for the past 90+ years has never been considered to be a fact and still remains a theory. I really wish I could get in touch with a GREAT doctor that knows a good deal about this stuff. I believe that with my previous extreme eating behaviors (specifically relating to massive carb loading in a short window before bedtime) and how my body reacts to what it considers low blood sugar at night now that I'm not eating all those carbs before bed is study-worthy and may be able to provide the community with some insight that it might not otherwise have been able to (legally) obtain.

I'm pretty sure that forcing or otherwise coercing somebody to eat the way that I did for as many years as I have in the name of science would be considered highly unethical, if not an outright violation of the Nuremberg Code. But here I am... All dialed in and ready to provide the data for the right person to study it.

You got any ideas about that, Sigs?

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Growing up in a Republic was nice... Shame we couldn't keep it.

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I'd need to research that SIX, it's way beyond what I know. But I'm oing to think my way thru this and you can tell me where my logic goes astray.

AFAIK, the waking phenomenon is the liver dumping sugar in the body preparing for waking up, and it's prompted by a release of cortisol. I'll bet there are other hormone changes going on, too, like melatonin, adrenaline, and so forth. This is a normal function, which can't be prevented, which only becomes problematic in ppl with diabetes bc it overwhelms the pancreas' ability to keep blood sugar under control.

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You can't prevent it, but Metformin and other biguanides decrease the amount of glucose produced by the liver, as well as decreasing the amount of glucose your digestive tract absorbs from food and improving your body's response to insulin. (The Glipizide I take does the 2nd two as well, but does not impact glucose production by the liver).

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The Somogyi effect is more like reactive HYPERglycemia - a response to HYPOglycemia that occurs some time earlier during the night. (The website I went to, I think it was the Mayo website, described the Somogyi effect as rare but real.) It is a reaction to ABnormally low blood sugar, and the sugar dump becomes problematic in ppl with diabetes bc it overwhelms the pancreas' ability to keep blood sugar under control.

So, the waking phenomenon can't be prevented, but can be managed with proper medication timing. The Somogyi effect, in theory, CAN be prevented by preventing whatever caused the hypoglycemia in the first place.

Your readings didn't demonstrate hypoglycemia, which possibly rules out a classic Somogyi effect. So I'm supposing that you suspect that your liver (and pancreas?) have been "trained" by your high-carb bedtime routine to ... store sugar at bedtime and dump it in the morning?

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Yeah. This is my theory. I realize that 90mg/dL is NOT hypoglycemia, but unlike my classic gradual rise in the early morning that usually happens around 4:00AM and persists for a few hours, no matter if I'm already at 130 or 170, this one happened 2 hours earlier than normal after I went to bed at 110 and dropped to 90 several hours later and literally took off like a rocket all the way to 280. That is a number 50 more than I've been in the 16 days that I've been wearing the monitor. I've never been over 230 until last night.

I can't help but think that even though I wasn't hypoglycemic that my body THINKS I was hypoglycemic since that 90 reading at 2AM last night may have been the first time my body even hit sub-100 while sleeping since the Cubs won the World Series.

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Not sure where you're going with this, especially how this is managed by treatment. One way, I suppose, is that since it took years of eating high carbs at bedtime it would take a few months of new eating habits to retrain your system to a new regimen, and I guess only patience and persistence would tell you if that's making a difference.

But in the meantime, it still needs to be managed, and so I guesss your question is do you want to continue with oral meds and see whether this spike eventually evens out? Or should you include insulin again, but this time maybe a bedtime injection of a form that starts acting in the relevant timeframe ... 4(?) hours?

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Oh... I wouldn't put that kind of question on you.

I'm wondering if you know how I would get in touch with anybody who might be interested in studying this.

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Have I more or less picked my way thru correctly?

As an analyst, I'd say you don't have enough data to decide, if that's the question you're trying to answer. When we were experimenting on dear daughter and trying different anticonvulsants in rapid succession, there was always an interim period when we wer weaning from one med and introducing another.

Your long-acting insulin may still be washing out of your system (takes five half-lives to wash out)

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I'm still taking the long-acting right now. I'm taking 12 units every morning somewhere around 9AM. I haven't had any rapid-active at all for at least 3 days, and even before that I'd had days where I didn't take it or I took an extremely minimal amount.

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Then, AFTER the new med was onboard it takes at least five half-lives to reach an equilibrium concentration. Your oral meds may not yet be up to effective concetration. Without knowing any of your particulars... exactly what form (extended release designated "ER"? enteric coat? regular?) and dosage and # per day of pills, and the date that you started back on oral meds, I can't even estimate when you'll reach equilibrium at your current dosage, but if you look up

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Just regular Metformin (1000mg every 12 hours) and Glipizide (5mg every 24 hours) other than the Long-Active 12 units of insulin.

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"half life" of metformin (of your specific type) in # hours. equilibrium is reached at

half life (in hours) X 5 = time to equibilibrium.

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I can't find data on a specific type or even dosage. I'm just seeing 17.6 x 5.5 = 96.8 hours.

I've taken it 3 mornings in a row now, and tonight will be the 4th night. Looks like I'll be at 96 hours there or about when I take tonight's pill, and last night I was only at roughly 72 hours when I took it, and probably in the area of 76 or 77 when I had my hyperglycemic liver dump.

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Then it takes some time to assess effectiveness. Fortunately for you, with the implant, ou get almost instant feedback.

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I can't really tell, actually. Ever since I had the meter my pattern has always been "rise during late night through morning, peak around noon, low in afternoon, stabalize at evening to early night".

This seems just as true on Metformin and Glipizide as it did when I was taking 8 more units of Long-Active and I was eating more carbs and using up to 30 units of Rapid-Active per day.

The difference now (on the oral meds), if I had to spot one is that my highs are higher, but they rise and lower much quicker than before and my lows aren't getting dangerously low in the afternoon anymore. The part about the lows could be that I've got a lot of free time though and I've gotten a lot better about eating around them so I can load up on my carbs when I get those free carbs not requiring an insulin shot. Although I have to say that I've only had about 60 carbs today which is going to end up being my record low if things stay the same. I had around 40 of them when I dipped this afternoon, and I've been in the mid 130s since. At this point of the night I don't expect it to go back down again anywhere close to the low 100s and for me to get another opportunity for free carbs, so I'll have to eat protien.

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Also, we tried to change only one thing at a time. Hard to do when you're desperate but having to go back over old ground is a massive waste of time. For you, there are other factors at play such as your new diet regimen and whatever your current activity level is. If you can try to keep everythin more or less the same.

So I don't know how long you feel comfortable running this experiment, but I think you need to give it more time to assess how it's working. A week, perhaps? Also, you need to decide how "good" is "good enough"? What range of blood sugar is acceptable TO YOU?

One piece of data that I DID pick out is that your blood sugar did eventually drop, so apparently your pancreas is still trying to keep up.

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Yeah. But how much of that is my own pancreas and the 12 units of Long-Active? Who knows?

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And finally, if I understand Type 1.5 correctly, you will need to be alert to the possibiity that even if oral meds are working now, at some point in the future they may fail to work.

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Yeah. I know. My C Peptides are already extremely low.

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Sorry for the long-windedness w/o a defnitive answer.

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Don't apologize. Thanks.

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Growing up in a Republic was nice... Shame we couldn't keep it.

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Originally posted by SIGNYM:
I guess what I was saying is ... when you're dealing in an area not well-known to anyone except obscure researchers, sometimes you have to design your own experiments and experiment on yourself.

You might find an answer at a university affiliated research hospital. Or you might need to do a deep deep dive into webforums dedicated to LADA and other unusual forms of diabetes. That's how I found our daughter's dx.

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Originally posted by Brenda:
Out for my walk in a bit and phone call set up with the poet helping me to look at another publisher.

My area got some rain last night but more was going to the Peace which needs it for sure.

Need some groceries and I might tackle some clean up when I get back.

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