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The anime project will not only remake the best episodes from the live-action version, but also depict original episodes not seen in the live-action version. Those original episodes will include prologues of the Winchester brothers' childhood, anime-only enemies, and episodes featuring secondary characters from the live-action version.

Supernatural creator Eric Kripke is credited as the anime project's creator, and MADHOUSE co-founder Masao Maruyama is serving as executive producer. Naoya Takayama (Night Head, Liar Game) is supervising the series' scripts, and Takahiro Yoshimatsu (Trigun) is designing the characters.

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