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“We don’t have accurate numbers,” insists Dr. James Neuenschwander, an expert on vaccine safety based in Ann Arbor, Michigan.
But what we do know, Neuenschwander says, is that the vaccines are not as effective as public health officials told us they would be. “This is a product that’s not doing what it’s supposed to do. It’s supposed to stop transmission of this virus and it’s not doing that.”

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Symptoms might include:4??

Fevers and chills
Fatigue
Swelling of extremities
Nausea and vomiting
Muscle and joint aches
Headache
Rash
Cough
Shortness of breath
Rapid breathing
Seizures
Tremor
Difficulty coordinating movements
Confusion and hallucinations
Lethargy and poor responsiveness

Very low blood pressure and increased blood clotting can also be hallmarks of severe cytokine storm syndrome. The heart may not pump as well as it normally would. As a result, cytokine storm can affect multiple organ systems, potentially leading to organ failure and death.
https://www.verywellhealth.com/cytokine-storm-syndrome-4842383

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Originally posted by 1KIKI:

So what's going on with Israel?

Israel has 3 extremely sharp COVID-19 peaks so far.

6276 cases/ 7 days Sep 27 2020
39 deaths / 7 days Oct 15 2020
CFR 0.62

8190 cases/ 7 days Jan 15 2021
65 deaths / 7 days Jan 25 2021
CFR 0.79

6991 cases/ 7 days Aug 21 2021
5923 cases/ 7 days Aug 9 2021
21 deaths / 7 days Aug 21 2021
CFR 0.35

Pfizer mass vaccination: Jan 1 - March 31 2021
Most eligible people were vaccinated 5-8 months ago, reaching a peak for the first vaccination wave of 57% of the total population.

Israel's vax eligibility age limit was 16, and about 25% of its population is under 16. So about 25% are unvaxed due to age, and by calculation about 18% are eligible unvaxed. So current cases are probably skewed to the young; and deaths have a 'youth discount'.

With that in mind, the current CFR at roughly half the previous CFR may be in part due to an age discount and not vaccination status.

Obviously these are 'back of the envelope' calculations; I'm sure the Israeli government has exact figures.

That might be why Israel is giving out booster shots. Vax effectiveness against death isn't as robust as they supposed.

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The good news is that among Israel's serious infections on Thursday of this week, according to Health Ministry data, the rate of serious cases among unvaccinated people over age 60 (178.7 per 100,000) was nine times more than the rate among fully vaccinated people of the same age category, and the rate of serious cases among unvaccinated people in the under-60 crowd (3.2 per 100,000) was a little more than double the rate among vaccinated people in that age bracket.

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Israel is the first country to offer a third shot of the Pfizer vaccine in a nationwide booster campaign. Preliminary research in Israel suggests booster shots significantly increase protection against the coronavirus a week after a person receives the third dose.

Israeli national HMO Maccabi Healthcare Services, which conducted the preliminary study of 149,144 Israelis who received three Pfizer shots, said for Israelis above age 60, a Pfizer booster shot reduced the chances of infection by 86% and reduced the chances of severe infection by 92%.

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After binding of SARS-CoV-2 to alveolar epithelial cells, production of a range of proinflammatory cytokines and chemokines, including GM-CSF and IL-6 occur, which in turn recruit more monocytes and macrophages and lead to a subsequent cytokine storm [21]. A great number of studies showed a raised level of various cytokines and chemokines including IL-2, IL-6, IL-7, IL-10, IL-17, G-CSF, GM-CSF, IP-10, MCP1, MIP1A, TNFa, IFN-?, VEGF, CCL2, etc. in more severe patients with COVID-19.

Although complete characteristics of cytokine storm in COVID-19 are yet to be specified, anti-cytokine mAb could play a crucial role in the case of severe COVID. Multiple IL-6 inhibitors including tocilizumab (phase 4), sarilumab (phase 3), and siltuximab are currently under investigation in clinical trials in several concerned groups. Among them, tocilizumab showed immediate improvement in the clinical outcomes of severe and critical patients, which proved to be an effective treatment for reducing mortality ...

A case-control study showed 80% reduction in relative risk of invasive ventilation and/or death in patients treated with lenzilumab [targets granulocyte macrophage colony-stimulating factor GM-CSF] compared with the control group [30]. In addition, the median time to resolution of ARDS reduced to one day along with early discharge from the hospital for patients treated with lenzilumab versus eight days to resolution...

A study conducted on 10 terminally ill COVID-19 patients observed complete CCR5 receptor occupancy by leronlimab (CCR5 antagonist) on macrophage and T cells, resulting in a rapid reduction of plasma IL-6, restoration of the CD4/CD8 ratio, and a significant decrease in SARS-CoV-2 plasma viremia [32]. A novel approach using leronlimab thus could play an important role in resolving unchecked inflammation, restoring immunologic deficiencies, and reducing SARS-CoV-2 plasma viral load via disruption of the CCL5-CCR5 axis

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Originally posted by 6IXSTRINGJACK:
Masks don't do anything because nobody is requiring people to wear N95 masks.

With what most people are covering their faces with it's like using a fishnet stocking as a condom.

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Considerations in boosting COVID-19 vaccine immune responses

Philip R Krause, Thomas R Fleming, Richard Peto, Ira M Longini, J Peter Figueroa, Jonathan A C Sterne, Alejandro Cravioto, Helen Rees, Julian P T Higgins, Isabelle Boutron, Hongchao Pan, Marion F Gruber, Narendra Arora, Fatema Kazi, Rogerio Gaspar, Soumya Swaminathan, Michael J Ryan, Ana-Maria Henao-Restrepo
https://www.thelancet.com/action/showPdf?pii=S0140-6736%2821%2902046-8
#page=1&;

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Current evidence does not, therefore, appear to show a need for boosting in the general population, in which efficacy against severe disease remains high. The ability of vaccines that present the antigens of earlier phases of the pandemic (the alpha strain) (rather than variant-specific antigens) to elicit humoral (antibody) immune responses against currently circulating variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune responses induced by those vaccines.
... careful observational studies that examine efficacy against severe disease remain useful and are less likely to be affected by diagnosis-dependent biases over time than are observational studies of milder disease, and could therefore provide useful indicators of any changes in vaccine-induced protection. (Monitoring for severe disease with new variants is more indicative of changing vax effectiveness, because there are too many confounding influences when looking at milder diseases.)
Although vaccines are less effective against asymptomatic disease or against transmission than against severe disease, even in populations with fairly high vaccination rates the unvaccinated are still the major drivers of transmission and are themselves at the highest risk of serious disease. The message that boosting might soon be needed, if not justified by robust data and analysis, could adversely affect confidence in vaccines and undermine messaging about the value of primary vaccination.
If boosters (whether expressing original or variant antigens) are ultimately to be used, there will be a need to identify specific circumstances in which the direct and indirect benefits of doing so are, on balance, clearly beneficial.
The vaccines that are currently available are safe, effective, and save lives. The limited supply of these vaccines will save the most lives if made available to people who are at appreciable risk of serious disease and have not yet received any vaccine. Even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated. If vaccines are deployed where they would do the most good, they could hasten the end of the pandemic by inhibiting further evolution of variants.

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Meanwhile, back in the US, the Washington Post just reported - in an "exclusive" scoop likely spoon-fed to its journalists - that the administration is planning to buy hundreds of millions of additional doses of the Pfizer-BioNTech jab to donate to less fortunate countries from around the world. The announcement is expected to be made around the start of next week's United Nations General Assembly meeting, though the details haven't yet been finalized.

Some might say the administration's latest "gift" is merely more transparent virtue signaling as Biden continues to push booster jabs in the US against the wishes of the WHO.

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Why Does No One Ever Talk About Sweden Anymore?
Friday, Sep 17, 2021 - 03:30 AM
Via 'Unmasked" substack,

One of the most consistently repeated trends of COVID has been the premature declarations of victory from areas with a perceived level of “success” in “controlling” the pandemic.

It’s happened in countries all over the world — Vietnam, Japan, Taiwan, Australia, Mongolia — just to name a few examples. They all have been praised for their ability to “control” the virus with masks and public health measures, only to then see cases invariably skyrocket.

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At the end of the day, right here, I'm the only person who's trying to tell people not to panic and the sky isn't falling.

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COVID-19 In Norway Can Now Be Compared To The Flu, Says Health Chief
Friday, Sep 24, 2021 - 03:30 AM

By Frazer Norwell of TheLocal.de

Coronavirus can now be categorised as one of several respiratory illnesses with seasonal variation, Geir Bukholm, assistant director of the Norwegian Institute of Public Health (NIPH), has said.

For the past year and a half, Covid-19 has been classed as a generally dangerous disease. However, this could change soon as the assistant director of the Norwegian Institute of Public Health (NIPH), Geir Bukholm, has said the coronavirus can now be put in the same category as illnesses such as flu, common colds and RS (respiratory syncytial virus).

“We are now in a new phase where we must look at the coronavirus as one of several respiratory diseases with seasonal variation,” Bukholm told paper VG.

Last week the Ministry of Health and Social Care asked the NIPH to assess whether Covid-19 was still a dangerous disease.

While the NIPH has yet to return its findings, its assistant director has made it clear that the danger of Covid will be downgraded.

Covid could now be compared in severity with the likes of colds and flu because the vast majority of those at most risk of developing severe disease when infected are now fully vaccinated.

“And although the infection is still circulating, hospital numbers remain low. Thus, the coronavirus will not lead to a heavy burden on the health service. For those vaccinated who may become infected and develop symptoms, the vast majority will have mild cold-like symptoms.”

However, Bukholm did warn that even though Covid could now be compared with other common respiratory illnesses, the pandemic was far from over.

"The pandemic is not over as long as it exists in the world and in countries where the vaccine coverage is still low. As long as the diseases spread throughout the world, there is still a pandemic,” Bukholm cautioned.

VG has speculated that the disease being downgraded could be a sign that the lifting of the final national Covid-19 restrictions could be just around the corner.

The paper points to Denmark and the lifting of restrictions there once coronavirus was no longer considered a dangerous disease.

Last week health minister Bent Høie offered a glimpse at what Norway would look like once measures were lifted but didn’t offer a date for when restrictions would be lifted.

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.Here's a little something I said back back in March of 2020.

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At the end of the day, right here, I'm the only person who's trying to tell people not to panic and the sky isn't falling.

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And I'm still doing it a year and a half later.

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At the end of the day, right here, I'm the only person who's trying to tell people not to panic and the sky isn't falling.

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Originally posted by 6IXSTRINGJACK:
lol

Go ahead and look at the posts from the first five months.

I'm not lying about what everybody else posted. You should all be embarrassed.

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Originally posted by 1KIKI:

We know Jack can have powerful anxiety, for example his anxiety about his house was enough for him to go on a multi-year non-stop bender. (And congratulations to Jack for finding a way to get past his anxiety, even though it was at the cost of believing the unreality that he's in complete control.)

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The house didn't put me on a bender. I put me on a bender.

I didn't have any issues with my house when I started drinking.

Then I fixed my drinking issue without any bullshit 12 step program or needing to "find God" first. My drinking was due to depression. Not anxiety.

I overcame that nearly life-ending adversity entirely on my own.

And after that, I fixed the house issues that crept up due to my negligence.

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I think Jack's answer to anything that's out of his control that makes him feel anxious is denial ... along with a hefty dose of projection. It's all 'their' fault for evilly trying to make him feel threatened with their 'lies' and 'panic'.

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I have zero anxiety about the pandemic, and have since day one.

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But enough about Jack.

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Yes. I agree. You should stop obsessing over me.



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Vaccinated People: "You need to get muh vaccination shots that don't work because I got muh vaccination shots that don't work and I'm afraid of people that didn't get muh vaccination shots that don't work because muh vaccination shots that don't work don't work."

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This Is A Game-Changer" - Merck Releasing "Phenomenal" Test Results For Experimental COVID Pill
Friday, Oct 01, 2021 - 07:45 AM

Looks like Merck just beat Pfizer to the punch.

Merck announced Friday that an experimental COVID pill it has developed reduced hospitalizations and deaths by 50% in people recently infected with COVID.

The company will soon ask health officials in the US and abroad to authorize use of the drug.

The news came as a welcome surprise to the public, although COVID cases are already waning in the US and in hard-hit economies in Asia, the drug could create "a real therapeutic advance" that could dramatically decrease the risk of death from COVID.

If approved (and odds are it will be) the drug would be the first treatment for COVID. Some compared it to tamiflu, in that patients should take it within 5 days of COVID infection (like those infected with the flu are instructed to take tamiflu early).

Former FDA Director Dr. Scott Gottlieb told CNBC that the trial results are clearly "profoundly" positive, even though researchers decided to stop the trial early because the drug showed significant success, meaning it would be unethical to keep giving patients placebos. To test the drug, they needed to test more than 700 unvaccinated people in a global study. The people were all considered in the "high risk" category due to factors like age, and other characteristics from their "health profile".

Per the results, 7% of volunteers in the group that received the drug were hospitalized, and none of them died, compared with a 14% rate of hospitalization and death (include eight who died) in the placebo group.

According to Dr. Gottlieb, "this is a phenomenal result. This is a profound game-changer that we have an oral pill that had this kind of effect on patients who are already symptomatic."

Dr. Gottlieb also pointed out that the team that developed the drug "also invented the first successful antibody against ebola so this is a very good drug-development team."

"And remember we have two other drugs in development one by Pfizer (where Dr. Gottlieb serves on the board) and the other by Roches," he said.

Patients won't be taking the drug for very long, typically around five days, which means "the safety profile is probably pretty good," Dr. Gottlieb said.

Per the NYT, "the Merck pill’s efficacy was lower than that of monoclonal antibody treatments, which mimic antibodies that the immune system generates naturally when fighting the virus. Those drugs have been in high demand recently, but they are expensive, are typically given intravenously, and have proved cumbersome and labor-intensive for hospitals and clinics to administer. Studies have shown that they reduce hospitalizations and deaths 70 to 85 percent in similar high-risk Covid patients."

The Merck drug is significantly chemically different from the Pfizer drug that's in its final round of studies, which means there's the possibility of creating a cocktail of anti-viral treatments for COVID. Merck has said it can produce 10MM pills by the end of this year, and Dr. Gottlieb said he expects they'll ramp up production quickly by partnering with other companies.

Merck partnered with a small firm called Ridgeback Biotherapeutics to develop the drug, which is called Molnupiravir. While the study results haven't yet been peer reviewed, at least one independent group of medical experts have given the research their blessing.

"This is a milestone in the fight against COVID," Dr. Gottlieb said.

So, is the prospect of a return to "normality" really on the table? I suppose we're about to find out.

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Originally posted by SIGNYM:
Unfortunately that's the way studies have to be done. In order to see if a treatment does any good you need one group who receives the "standard of care" (control) and the other group who receives the new treatment. The "gold standard" is whar they call "double blind", in which the control group gets a placebo (in this case, that would be a lookalike pill) where neither the control group nor the medical staf know who is getting what. That prevemts unsonscious bias from either the patients or the medical staff from creepong in and affecting either the actions or evaluations of the staff.

But whether theyre doing randomized, double-blind or "open" studies, they have to enroll patients under "informed consent". They don't just randomly pick and choose.

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I was recently offerred the option of being in two clinical trials (one randomized, one open). I declined both.

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Originally posted by SIGNYM:
Some people are looking for freebie evaluation and treatment for their ailment.

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Sometimes people join them out of the goodness of their hearts for the advancement of science.

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Sometimes people join them as a last desperate gamble to cure an incurable disease.

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Originally posted by 6IXSTRINGJACK:
So we're either pretending that they weren't murdered for Science, or we're perfectly fine with the fact.

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Vaccinated People: "You need to get muh vaccination shots that don't work because I got muh vaccination shots that don't work and I'm afraid of people that didn't get muh vaccination shots that don't work because muh vaccination shots that don't work don't work."

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Originally posted by SIGNYM:

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Originally posted by 6IXSTRINGJACK:
So we're either pretending that they weren't murdered for Science, or we're perfectly fine with the fact.

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Vaccinated People: "You need to get muh vaccination shots that don't work because I got muh vaccination shots that don't work and I'm afraid of people that didn't get muh vaccination shots that don't work because muh vaccination shots that don't work don't work."

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The benefits and risks are explained in layman's terms, and the patient makes a choice.

I can't explain why people makes the choices they do. Maybe some of them believed, as you do, that "people don't die of Covid". Maybe some of them were as paranoid about an experimental pill as you are about an "unapproved" mRNA vaccine.

But you do realize that you just admitted that people do, indeed, die of Covid. Right?

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Originally posted by 6IXSTRINGJACK:
P.S. Even in the fake news on the subject, you've got a 99.6% chance of surviving Covid without a vaccine.

This test just happened to magically stumble on a whole ton of people who were going to die of Covid and give a ridiculous percentage of deaths in the study to prove that they died because they only had a placebo.

Will you listen to yourself? You're not this stupid.

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Originally posted by SIGNYM:



The total number of deaths across the USA, according to the MSM, is 700,000. Infection fatality rate 0.7 pct population-wide.

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Yet Biden has DOUBLED the Deaths of Trump?

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